IMMUNOBIOLOGY Functional heterogeneity of human effector CD8 T cells
نویسندگان
چکیده
Effector CD8 T cells are believed to be terminally differentiated cells having cytotoxic activity and the ability to produce effector cytokines such as INFand TNF. We investigated the difference between CXCR1 and CXCR1 subsets of human effector CD27 CD28 CD8 T cells. The subsets expressed cytolytic molecules similarly and exerted substantial cytolytic activity, whereas only the CXCR1 subset had IL-2 productivity and self-proliferative activity and was more resistant to cell death than the CXCR1 subset. These differences were explained by the specific up-regulation of CAMK4, SPRY2, and IL-7R in the CXCR1 subset and that of pro-apoptotic deathassociated protein kinase 1 (DAPK1) in the CXCR1 subset. The IL-2 producers were more frequently found in the IL-7R subset of the CXCR1 effector CD8 T cells than in the IL-7R subset. IL-7/ IL-7R signaling promoted cell survival only in the CXCR1 subset. The present study has highlighted a novel subset of effector CD8 T cells producing IL-2 and suggests the importance of this subset in the homeostasis of effector CD8 T cells. (Blood. 2012;119(6):1390-1398)
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